Publications

Glyco-Checkpoints and Tumor Immunosuppression
Glyco-Checkpoints in Vascularization Processes
Colorectal cancer (CRC)
Pancreatic ductal adenocarcinoma (PDAC)
Breast cancer
Glioblastoma
Liver cancer
Kidney cancer
Lung cancer
Skin cancer
Autoimmunity and Inflammation
Autoimmunity and InflammationGlyco-Checkpoints and Tumor ImmunosuppressionGlyco-Checkpoints in Vascularization ProcessesAll

Glycan-Binding Proteins in Immunity

Rabinovich GA, et al - Annu Rev Immunol. 2026 Apr
Pancreatic ductal adenocarcinoma (PDAC)

Nuclear Galectin-1 promotes KRAS-dependent activation of pancreatic cancer stellate cells

Cagnoni AJ, et al - Proc Natl Acad Sci U S A. 2021 May
Glyco-Checkpoints and Tumor Immunosuppression

A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1...

Li R, et al - Sci Transl Med. 2024 Oct
Glyco-Checkpoints in Vascularization Processes

Circulating galectin-1 delineates response to bevacizumab in melanoma patients and reprograms...

Bannoud N, et al - Proc Natl Acad Sci U S A. 2023 Jan
Glyco-Checkpoints and Tumor Immunosuppression

Targeting galectin-driven regulatory circuits in cancer and fibrosis

Mariño KV, et al - Nat Rev Drug Discov. 2023 Apr
Skin cancerGlyco-Checkpoints and Tumor Immunosuppression

Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs

Pinto NA, et al - Cell Death Differ. 2023 Apr
Autoimmunity and Inflammation

Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm

Roldán-Montero R, et al - Sci Adv. 2022 Mar
Colorectal cancer (CRC)

Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8+...

Cagnoni AJ, et al - Proc Natl Acad Sci U S A. 2021 May
Autoimmunity and Inflammation

Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits

Morosi LG, et al - Sci Adv. 2021 Jun
Autoimmunity and Inflammation

Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a...

Russo AJ, et al - Nat Immunol. 2021 Feb
Autoimmunity and Inflammation

Suppression of age-related salivary gland autoimmunity by glycosylation-dependent galectin-1-driven immune inhibitory...

Martínez Allo VC, et al - Proc Natl Acad Sci U S A. 2020 Mar

Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune...

Segovia M, et al - Cancer Cell. 2019 May
Glyco-Checkpoints and Tumor Immunosuppression

IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial...

Song M, et al - Nature. 2018 Oct
Pancreatic ductal adenocarcinoma (PDAC)

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk

Orozco CA, et al - Proc Natl Acad Sci U S A. 2018 Apr
Breast cancer

Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation

Rutkowski MR, et al - Cancer Cell. 2015 Jan
Breast cancerGlyco-Checkpoints and Tumor Immunosuppression

Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease

Dalotto-Moreno T, et al - Cancer Res. 2013
Glyco-Checkpoints and Tumor Immunosuppression

A Unique Galectin Signature in Human Prostate Cancer Progression Suggests Galectin-1...

Laderach DJ, etc al - Cancer Res. 2013 Jan
Autoimmunity and Inflammation

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer

Rabinovich GA, Croci DO. - Immunity. 2012 Mar
Autoimmunity and Inflammation

Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration

Starossom SC, et al - Immunity. 2012 Aug
Skin cancerGlyco-Checkpoints in Vascularization Processes

Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in...

Croci DO, et al - J Exp Med. 2012 Oct
Skin cancer

Tolerogenic signals delivered by dendritic cells to T cells through a...

Ilarregui JM, et al - Nat Immunol. 2009 Sep
Autoimmunity and Inflammation

A pivotal role for galectin-1 in fetomaternal tolerance

Blois SM, et al - Nat Med. 2007 Dec
Autoimmunity and Inflammation

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates...

Toscano MA, et al - Nat Immunol. 2007 Aug
Skin cancerGlyco-Checkpoints and Tumor Immunosuppression

Targeted inhibition of galectin-1 gene expression in tumor cells results in...

Rubinstein N, et al - Cancer Cell. 2004 Mar
PublicationsAll

Regulated expression of a 16-kd galectin-like protein in activated rat macrophages

Rabinovich, G et al. Journal of leukocyte biology vol. 59,3 (1996)